One of the first man-made radioisotopes was Gold - 198 ( 198Au) used for prostate permanent seed implantation. Naturally occurring radioisotopes are not ideal sources for permanent seed implantation.
Historically, radium was used therapeutically within a decade of its discovery for intracavitary prostate brachytherapy. Permanent prostate seed implantation is a minimally invasive approach to implant low activity radioactive sources to the prostate gland with the guidance of transperineal ultrasound technique.
